Package: Certara.RsNLME
Title: Pharmacometric Modeling
Version: 3.2.0
Authors@R: c(person("James", "Craig", email = "james.craig@certara.com", role = c("aut", "cre")),
      person("Michael", "Tomashevskiy", email = "michael.tomashevskiy@certara.com", role = c("aut")),
      person("Vitalii", "Nazarov", email = "vitalii.nazarov@certara.com", role = c("aut")),
      person("Shuhua", "Hu", email = "shuhua.hu@certara.com", role = c("ctb")),
      person("Fred", "Soltanshahi", email = "fred.soltanshahi@certara.com", role = c("aut")),
      person("Certara USA, Inc.", role = c("cph","fnd"))
      )
Description: Facilitate Pharmacokinetic (PK) and Pharmacodynamic (PD) modeling
    and simulation with powerful tools for Nonlinear Mixed-Effects (NLME)
    modeling. The package provides access to the same advanced Maximum Likelihood
    algorithms used by the NLME-Engine in the Phoenix platform. These tools support
    a range of analyses, from parametric methods to individual and pooled data, and
    support integrated use within the Pirana pharmacometric workbench
    <doi:10.1002/psp4.70067>. Execution is supported both locally or on
    remote machines.
Depends: R (>= 4.0)
License: LGPL-3
URL: https://certara.github.io/R-RsNLME/
Encoding: UTF-8
LazyData: true
Suggests: rlang, knitr, rmarkdown, testthat, magrittr, ellmer (>=
        0.4.0), callr (>= 3.7.0), ps (>= 1.7.0), withr, digest, curl,
        flextable
Imports: xml2, assertthat, Certara.NLME8 (>= 3.2.0), data.table,
        jsonlite, methods, utils, ssh
Collate: 'NlmePmlModelInfo.R' 'NlmeRandParamsMapping.R'
        'NlmeParamsMapping.R' 'NlmeDoseMapping.R'
        'NlmeEmaxParameters.R' 'NlmeIndirectParameters.R'
        'NlmeModelAbsorption.R' 'NlmeModelParameterization.R'
        'NlmePkParameters.R' 'NlmeModelType.R' 'NlmeDataset.r'
        'NlmeColumnMapping.r' 'error_model.r' 'NlmeRandomEffectBlock.r'
        'pml_model.r' 'BootstrapParams.R' 'NlmeParallelMethod.R'
        'NlmeUserAuthentication.R' 'NlmeParallelHost.R'
        'nlme_job_helpers.R' 'SimpleNlmeJob.R' 'BootNlmeJob.R'
        'CovariateEffectModel.R' 'engine_params.r' 'FitNlmeJob.R'
        'GenerateControlfile.R' 'GenerateParamsfile.R'
        'NlmeCovariateParameter.r' 'NlmeRemoteExecutor.R'
        'NlmeScenario.R' 'NlmeTableDef.R' 'SortColumns.R'
        'ProfileParameters.R' 'ProfileNlmeJob.R' 'ProfileVar.R'
        'RandomEffectsMethods.R' 'ShotgunNlmeJob.R' 'SortByNlmeJob.R'
        'StepwiseParams.R' 'StepwiseNlmeJob.R' 'acceptAllEffects.R'
        'addInfusion.R' 'addLabel.R' 'addTablesToColumnMapping.R'
        'add_input_dosingCycles.R' 'scmArchiveHelpers.R'
        'readFitSummary.R' 'jobCollectionHelpers.R'
        'loadBootstrapResult.R' 'bootstrap.r' 'bootstrapPrint.R'
        'built_in_models.r' 'cad_auth.R' 'checkHostParams.R'
        'colMapping.R' 'colMapping_validate.R' 'profilePrint.R'
        'profile_estimation.r' 'scmPrint.R' 'fitmodelHelperFunctions.R'
        'vpc.r' 'collectJob.R' 'copyModel.R' 'cov_validators.R'
        'covariateModel.R' 'covariateNames.R' 'createInitialMapping.R'
        'create_metamodel_from_model.R' 'create_model_from_metamodel.R'
        'create_model_info.R' 'data.r' 'dosing.r' 'editModel.R'
        'emaxmodel.R' 'extract_mmdl.R' 'fitmodel.R' 'fitmodelPrint.R'
        'fixedEffect.R' 'formatOutputForPirana.R'
        'generateCovarSearchArgsFile.R' 'getThetas.R'
        'get_omega_omegaSE.R' 'globals.R' 'hostParams.R'
        'imputeMissingCovariates.R' 'isPopulation.R' 'job.r'
        'jobLaunchHelpers.R' 'linearmodel.R' 'log_Execution.R'
        'map_covariates.R' 'map_dosepoints.R' 'mcp_analysis_plan.R'
        'mcp_blq.R' 'mcp_bootstrap_summary.R' 'mcp_compare.R'
        'mcp_covariate_search.R' 'mcp_data.R' 'mcp_deps.R'
        'mcp_execution.R' 'mcp_fit_spec.R' 'mcp_literature.R'
        'mcp_mmdl_scaffold.R' 'mcp_model_inspect.R' 'mcp_nonmem.R'
        'mcp_ofv_parity.R' 'mcp_perf.R' 'mcp_provider_runtime.R'
        'mcp_qc_readiness.R' 'mcp_repro_hooks.R' 'mcp_scm_summary.R'
        'mcp_sequential_lrt.R' 'mcp_textual_inspect.R'
        'mcp_tools_register.R' 'mcp_update_parameters.R'
        'mcp_validate.R' 'mcp_vpc_summary.R' 'mcp_workflow.R'
        'mmdl_io.R' 'modelVariableNames.R' 'model_designer.R'
        'null_default.R' 'observation.r' 'obtain_NLMELicense.R'
        'parameterNames.R' 'parseControlFile.R' 'parsePMLColMap.R'
        'parse_mmdl.R' 'pkemaxmodel.R' 'pkindirectmodel.R'
        'pklinearmodel.R' 'pkmodel.R' 'randomEffect.R'
        'run_metamodel.R' 'saveModel.R' 'saveUpdatedMetamodel.R'
        'scmAccess.R' 'scmSearchTable.R' 'scmSummary.R'
        'secondary_variable.r' 'shotgunSearch.R' 'simParams.R'
        'sortfit.R' 'stepwiseSearch.R' 'structural_param.r'
        'tableParams.R' 'update_PMLwithThetas.R' 'update_parameters.R'
        'writeColumnMapping.R' 'writeDefaultFiles.R'
Config/roxygen2/version: 8.1.0
NeedsCompilation: no
Packaged: 2026-09-14 19:59:40 UTC; jcraig
Author: James Craig [aut, cre],
  Michael Tomashevskiy [aut],
  Vitalii Nazarov [aut],
  Shuhua Hu [ctb],
  Fred Soltanshahi [aut],
  Certara USA, Inc. [cph, fnd]
Maintainer: James Craig <james.craig@certara.com>
Repository: CRAN
Date/Publication: 2026-09-15 02:20:41 UTC
