tsdf: Two-/Three-Stage Designs for Phase 1&2 Clinical Trials

Calculates Zhong's optimal two-/three-stage Phase II designs for single-arm trials, generates target-toxicity decision tables for two-/three-stage Phase I dose-finding, and supports dose-finding simulations using custom decision tables. The Phase II design is based on Zhong (2012) <doi:10.1016/j.cct.2012.07.006>.

Version: 1.1-9
Suggests: knitr, rmarkdown
Published: 2026-04-26
DOI: 10.32614/CRAN.package.tsdf
Author: Wenchuan Guo [aut, cre], Jianan Hui [aut], Bob Zhong [aut]
Maintainer: Wenchuan Guo <wguo1017 at gmail.com>
License: GPL-2
NeedsCompilation: no
Materials: README, NEWS
CRAN checks: tsdf results

Documentation:

Reference manual: tsdf.html , tsdf.pdf
Vignettes: Quick Start Guide (source, R code)

Downloads:

Package source: tsdf_1.1-9.tar.gz
Windows binaries: r-release: tsdf_1.1-8.zip, r-oldrel: tsdf_1.1-8.zip
macOS binaries: r-release (arm64): tsdf_1.1-8.tgz, r-oldrel (arm64): tsdf_1.1-8.tgz, r-release (x86_64): tsdf_1.1-8.tgz, r-oldrel (x86_64): tsdf_1.1-8.tgz
Old sources: tsdf archive

Linking:

Please use the canonical form https://CRAN.R-project.org/package=tsdf to link to this page.